Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin.

  title={Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin.},
  author={J. Kross and W. Henner and S. Hecht and W. Haseltine},
  volume={21 18},
  • J. Kross, W. Henner, +1 author W. Haseltine
  • Published 1982
  • Chemistry, Medicine
  • Biochemistry
  • The sites of cleavage of DNA by bleomycin A2, bleomycin B2, phleomycin, tallysomycin A, and Blenoxane (Bristol-Meyers) in reactions containing equimolar Fe2+ and atmospheric oxygen were analyzed by gel electrophoresis of 32P end labeled DNA fragments. Bleomycin A2 and bleomycin B2 reactions cleaved DNA at all sites with a frequency equal to that of Blenoxane. At high concentrations of bleomycin the site specificity of cleavage was unchanged. Bleomycin cleavage sites and phleomycin cleavage… CONTINUE READING
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