Specificity of brain cathepsin D: cleavage of model peptides containing the susceptible Phe-Phe regions of myelin basic protein.

@article{Marks1980SpecificityOB,
  title={Specificity of brain cathepsin D: cleavage of model peptides containing the susceptible Phe-Phe regions of myelin basic protein.},
  author={Neville Marks and Myron Benuck and George A. Hashim},
  journal={Journal of neuroscience research},
  year={1980},
  volume={5 3},
  pages={217-23}
}
Brain cathepsin D, purified by affinity chromatography on Sepharose pepstatin columns, was incubated with synthetic peptides corresponding to the susceptible regions of the myelin basic protein encompassing the two Phe-Phe bonds. One peptide, Leu-Gly-Arg-Phe-Phe-Gly-Gly, was cleaved by cathepsin D at the Phe-Phe bond while another, Val-His-Phe-Phe-Lys-Asn-Gly, was resistant to cleavage. To determine if this was a result of His flanking the Phe-Phe bond, or chain length on the N-terminal side… CONTINUE READING

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