Specificity of beta-adrenergic control of lipolysis in swine adipose tissue.

  title={Specificity of beta-adrenergic control of lipolysis in swine adipose tissue.},
  author={Harry John Mersmann},
  journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
  volume={77 1},
Fenoterol (beta 2-agonist) and several analogs stimulated swine adipose tissue lipolysis in addition to epinephrine, norepinephrine and isoproterenol. Lipolytic activity was inhibited by propranolol (beta 1 + beta 2) greater than metoprolol (beta 1) greater than ICI 118,551 (beta 2) greater than practolol (beta 1) much greater than butoxamine (beta 2) regardless of the agonist used in the test system. The swine adipose adrenoceptor is not readily classified into a beta 1 or beta 2 subtype. It… CONTINUE READING

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