Specificity of asbestos-induced chromosomal aberrations in short-term cultured human mesothelial cells.

@article{Olofsson1989SpecificityOA,
  title={Specificity of asbestos-induced chromosomal aberrations in short-term cultured human mesothelial cells.},
  author={Kjell Olofsson and Joachim Mark},
  journal={Cancer genetics and cytogenetics},
  year={1989},
  volume={41 1},
  pages={33-9}
}
Short-term cultured normal human mesothelial cells were exposed for 48 hours to three different asbestos compounds, crocidiolite, chrysotile, and amosite. In the concentration used (0.01 mg/ml) all three asbestiform minerals caused, within a few days, a significant increase of cells showing numerical and/or structural abnormalities. The abnormalities were analyzed in detail using banding techniques. The results were compared with the cytogenetic observations in 52 published cases of… CONTINUE READING

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