Specificity of PS integrin function during embryogenesis resides in the alpha subunit extracellular domain.

@article{MartnBermudo1997SpecificityOP,
  title={Specificity of PS integrin function during embryogenesis resides in the alpha subunit extracellular domain.},
  author={Mar{\'i}a D Mart{\'i}n-Bermudo and Olga M. Dunin-Borkowski and Nicholas H. Brown},
  journal={The EMBO journal},
  year={1997},
  volume={16 14},
  pages={4184-93}
}
We tested the ability of different integrin alpha subunits to substitute for each other during embryonic development. Two alpha subunits, which form heterodimers with the same betaPS subunit, are expressed in complementary tissues in the Drosophila embryo, with alphaPS1 expressed in the epidermis and endoderm, and alphaPS2 expressed in the mesoderm. As a result the two integrin heterodimers are present on opposite surfaces at sites of interaction between the mesoderm and the other cell layers… CONTINUE READING
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