Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation.

@article{Sabbagh2001SpecificityOM,
  title={Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation.},
  author={Walid Sabbagh and Laura J Flatauer and A Jane Bardwell and Lee Bardwell},
  journal={Molecular cell},
  year={2001},
  volume={8 3},
  pages={683-91}
}
Signals transmitted by common components often elicit distinct (yet appropriate) outcomes. In yeast, two developmental options-mating and invasive growth-are both regulated by the same MAP kinase cascade. Specificity has been thought to result from specialized roles for the two MAP kinases, Kss1 and Fus3, and because Fus3 prevents Kss1 from gaining access to the mating pathway. Kss1 has been thought to participate in mating only when Fus3 is absent. Instead, we show that Kss1 is rapidly… CONTINUE READING

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