Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy

@article{Jrvinen2007SpecificityOI,
  title={Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy},
  author={Kirsi M J{\"a}rvinen and Kirsten Beyer and Leticia Vila and Ludmilla Bardina and Michelle Mishoe and Hugh A. Sampson},
  journal={Allergy},
  year={2007},
  volume={62}
}
Background:  Approximately two‐thirds of egg‐allergic infants become tolerant within the first 5 years of life. 
Relationship between specific IgE to egg components and natural history of egg allergy in Danish children
The majority of egg‐allergic children develop tolerance over time. However, it may take numerous of consecutive egg challenges to get there as no good indices to predict tolerance exist.
Detection of specific IgE against linear epitopes from Gal d 1 has additional value in diagnosing hen’s egg allergy in adults
  • A. Ehlers, H. Otten, +4 authors W. Suer
  • Biology, Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2020
TLDR
Sensitization to hen's egg extracts, components and linear epitopes is solely studied in children, making accurate diagnosis in adults necessary.
Ovomucoid (Gal d 1) specific IgE detected by microarray system predict tolerability to boiled hen's egg and an increased risk to progress to multiple environmental allergen sensitisation
  • C. Alessandri, D. Zennaro, +5 authors A. Mari
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2012
TLDR
Detecting hen's egg (HE) allergy outgrowing and reintroduction of food containing egg is a task for the allergist.
Clinical Significance of Specific IgE Antibody Levels to Egg White, Ovalbumin and Ovomucoid in Egg Allergic Children Under 24 Months
TLDR
This data indicates that the total IgE and specific IgE antibody levels in the blood are higher in men than in women, and the IgE/IgE antibody level in women is higher than in men.
Oral immunotherapy with low allergenic hydrolysed egg in egg allergic children
TLDR
Both safety and efficacy of a low allergenic hydrolysed egg (HydE) preparation used in a double‐blind placebo‐controlled randomized study in egg allergic children are assessed.
Evaluation of baked egg oral immunotherapy in French children with hen's egg allergy
TLDR
The purpose of the study was to evaluate the efficacy and safety of baked egg oral immunotherapy (OIT) in children with HE allergy after a low‐dose baked egg Oral food challenge (OFC).
Immunoglobulin‐E‐binding epitopes of wheat allergens in patients with food allergy to wheat and in mice experimentally sensitized to wheat proteins
TLDR
This work has shown that B cell epitopes involved in food allergy to wheat are known only for a few allergens and a few categories of patients, and the importance of knowing these epitopes for diagnosis and treatment is still under debated.
Is epitope recognition of shrimp allergens useful to predict clinical reactivity?
TLDR
Diagnosis of shrimp allergy is still inaccurate, requiring the need for double‐blind, placebo‐controlled food challenges (DBPCFC), and a better understanding of the relationship between laboratory findings and clinical reactivity is needed.
A longitudinal study of resolution of allergy to well‐cooked and uncooked egg
  • A. Clark, S. Islam, +4 authors P. Ewan
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2011
TLDR
This data indicates that re‐introduction of well‐cooked egg to children with a history of egg allergy is a viable option and resolution to uncooked egg has been demonstrated.
Detection and control of eggs as a food allergen
TLDR
This chapter provides a basic overview of egg allergy, allergens in egg white and yolk, and quantitative and qualitative methods for detecting egg proteins in processed foods.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy
TLDR
This data indicates that around 85% of milk‐allergic children become clinically tolerant to CM within the first 3 years of life, and the mechanisms involved in the achievement of tolerance remain unknown.
Novel B and T cell epitopes of chicken ovomucoid (Gal d 1) induce T cell secretion of IL‐6, IL‐13, and IFN‐γ
  • E. Holen, B. Bolann, S. Elsayed
  • Medicine, Biology
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2001
TLDR
Background Chicken ovomucoid has an important role in the pathogenesis of IgE‐mediated allergic reactions to hen's egg white and its role in this work is still under investigation.
A Clinical and Immunological Study of Allergy to Hen's Egg White
Allergens in hen's egg white were studied in crossed radio‐immunoelectrophoresis (CRIE). Specific IgE‐antibodies against different proteins in the egg white were examined in sera from 70 atopic
Outcome of double‐blind, placebo‐controlled food challenge tests in 107 children with atopic dermatitis
TLDR
Little is known about late phase clinical reactions during oral food challenges and the value of specific IgE in terms of sensitivity and specificity and the need for further research into this area.
Clinical Significance of IgE–Binding Activity to Enzymatic Digests of Ovomucoid in the Diagnosis and the Prediction of the Outgrowing of Egg White Hypersensitivity
TLDR
IgE–binding activity to pepsin–digested ovomucoid was of diagnostic value to distinguish the challenge–positive subjects from the negative subjects and are unlikely to outgrow egg white allergy.
Allergenic properties of ovomucoid in man.
TLDR
The results indicate a dichotomy between T and B cell domain dominance, and the presence of both unique and common IgE and IgG epitopes, and suggest that conformational B cell epitopes play a more significant role in ovomucoid allergenicity than previously appreciated, and that carbohydrate moieties have a minor effect on allergenic properties.
[Antigenic determinants on ovalbumin and ovomucoid: comparison of the specificity of IgG and IgE antibodies].
TLDR
It is strongly suggested that antibodies to OA recognize partially conformational antigenic determinants on OA, whereas antibodies toOVM mainly recognize sequential antigenic determination on OVM, and that antigenIC determinants of OVM recognized by antibodies in sera from patients are more stable than those of OA under these denaturation conditions.
Detection of four distinct groups of hen egg allergens binding IgE in the sera of children with egg allergy.
TLDR
It is demonstrated that there were four distinct groups of patients reacting in a similar way to four discrete sets of proteins, and the existence of patient groups may explain why various workers have reported different allergens to be important in egg hypersensitivity.
Allergens in the white and yolk of hen's egg. A study of IgE binding by egg proteins.
The radioallergosorbent test (RAST) was used to compare the IgE binding of egg white and yolk, and allergenic proteins were detected by immunoelectrotransfer ('Western blotting'). The main allergens
Immunochemical identification of the allergens in egg white.
  • D. Hoffman
  • Chemistry, Medicine
    The Journal of allergy and clinical immunology
  • 1983
TLDR
The sera of patients who experienced gastrointestinal symptoms from ingestion of egg white were less reactive with ovomucoid than sera from patients with other symptoms, and there was no significant association of pattern of reactivity with age, sex, or presence of eczema.
...
1
2
3
4
...