Specificity of Distalless repression and limb primordia development by abdominal Hox proteins.

@article{Gebelein2002SpecificityOD,
  title={Specificity of Distalless repression and limb primordia development by abdominal Hox proteins.},
  author={B. Gebelein and J. Culi and H. Ryoo and W. Zhang and R. Mann},
  journal={Developmental cell},
  year={2002},
  volume={3 4},
  pages={
          487-98
        }
}
In Drosophila, differences between segments, such as the presence or absence of appendages, are controlled by Hox transcription factors. The Hox protein Ultrabithorax (Ubx) suppresses limb formation in the abdomen by repressing the leg selector gene Distalless, whereas Antennapedia (Antp), a thoracic Hox protein, does not repress Distalless. We show that the Hox cofactors Extradenticle and Homothorax selectively enhance Ubx, but not Antp, binding to a Distalless regulatory sequence. A C… Expand

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