Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA.

@article{Sklhegg2000SpecificityIT,
  title={Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA.},
  author={Bj\orn S Sk{\aa}lhegg and Kjetil Task{\'e}n},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2000},
  volume={5},
  pages={D678-93}
}
A large number of hormones, neurotransmitters and other signal substances utilize adenosine 3',5' cyclic monophosphate (cAMP) as an intracellular second messenger. Cyclic AMP regulates a number of different cellular processes such as cell growth and differentiation, ion channel conductivity, synaptic release of neurotransmitters, and gene transcription. The principle intracellular target for cAMP in mammalian cells is the cAMP-dependent protein kinase (PKA). The fact that this broad specificity… CONTINUE READING
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