Specificity in molecular design: a physical framework for probing the determinants of binding specificity and promiscuity in a biological environment.


Binding specificity is an important consideration in drug design. An effective drug molecule often must bind with high specificity to its intended target in the body; lower specificity implies the possibility of significant binding to unintended partners, which could instigate deleterious side effects. However, if the target is a rapidly mutating agent, a… (More)


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