Specificity in mineralocorticoid versus glucocorticoid action.

  title={Specificity in mineralocorticoid versus glucocorticoid action.},
  author={Peter J. Fuller and Sylvia S Lim-Tio and Francine E. Brennan},
  journal={Kidney international},
  volume={57 4},
The mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR) share considerable structural and functional homology. Overlapping effects on epithelial sodium transport are observed in vivo; in vitro, both are able to bind and transactivate through a common hormone response element. This has led several investigators to suggest that specificity is conferred primarily by prereceptor mechanisms, and we have addressed this question using both in vitro and in vivo approaches. Although the… CONTINUE READING