Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

  title={Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6},
  author={Hans H{\"a}cker and Vanessa Redecke and Blagoy Blagoev and Irina Kratchmarova and Li-Chung Hsu and Gang Greg Wang and Mark P. Kamps and Eyal Raz and Hermann Wagner and Georg H{\"a}cker and Matthias Mann and Michael Karin},
Toll-like receptors (TLRs) are activated by pathogen-associated molecular patterns to induce innate immune responses and production of pro-inflammatory cytokines, interferons and anti-inflammatory cytokines. TLRs activate downstream effectors through adaptors that contain Toll/interleukin-1 receptor (TIR) domains, but the mechanisms accounting for diversification of TLR effector functions are unclear. To dissect biochemically TLR signalling, we established a system for isolating signalling… CONTINUE READING
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