Specificity in Computational Protein Design*

  title={Specificity in Computational Protein Design*},
  author={James J Havranek},
  booktitle={The Journal of biological chemistry},
A long-standing goal of computational protein design is to create proteins similar to those found in Nature. One motivation is to harness the exquisite functional capabilities of proteins for our own purposes. The extent of similarity between designed and natural proteins also reports on how faithfully our models represent the selective pressures that determine protein sequences. As the field of protein design shifts emphasis from reproducing native-like protein structure to function, it has… CONTINUE READING