Specificity determinants in MAPK signaling to transcription factors.

  title={Specificity determinants in MAPK signaling to transcription factors.},
  author={Dalia Barsyte-Lovejoy and Alex Galanis and Andrew D Sharrocks},
  journal={The Journal of biological chemistry},
  volume={277 12},
One critical component in determining the specificity, fidelity, and efficiency of MAPK substrate phosphorylation is the presence of distinct docking domains in the substrate proteins. These docking domains are found in a range of substrates, including the transcription factors myocyte enhancer factor-2A and SAP-1. However, the sequences of these motifs differ, as does their targeting preferences by MAPKs, with SAP-1 being targeted by both the ERK and p38 isoforms, whereas myocyte enhancer… CONTINUE READING

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