Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction.

@article{Li2005SpecificityAV,
  title={Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction.},
  author={Shawn S. C. Li},
  journal={The Biochemical journal},
  year={2005},
  volume={390 Pt 3},
  pages={
          641-53
        }
}
Protein-protein interactions occurring via the recognition of short peptide sequences by modular interaction domains play a central role in the assembly of signalling protein complexes and larger protein networks that regulate cellular behaviour. In addition to spatial and temporal factors, the specificity of signal transduction is intimately associated with the specificity of many co-operative, pairwise binding events upon which various pathways are built. Although protein interaction domains… CONTINUE READING
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The SH3 domain--a family of versatile peptide- and protein-recognition module.

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