Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-39).

@article{Hoare2002SpecificityAS,
  title={Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7-39).},
  author={Samuel R J Hoare and Ted B Usdin},
  journal={Peptides},
  year={2002},
  volume={23 5},
  pages={989-98}
}
Parathyroid hormone 1 (PTH1) receptor antagonists might be of benefit in hypercalcemia of malignancy (HHM) and hyperparathyroidism. We previously identified bovine tuberoinfundibular peptide (7-39) (bTIP(7-39)) as a high-affinity PTH1 receptor antagonist. Mouse TIP(7-39) is an antagonist (rPTH1 K(B)=44 nM, rPTH2=940 nM) that is more potent than other known PTH1 receptor antagonists: bTIP(7-39) (210 nM), PTH-related protein (PTHrP)(7-34) (640 nM), and bPTH(7-34) (>3000 nM). Plasma proteases… CONTINUE READING

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