Specificity and robustness in transcription control networks.

  title={Specificity and robustness in transcription control networks.},
  author={Anirvan M. Sengupta and Marko Djordjevic and Boris I. Shraiman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 4},
Recognition by transcription factors of the regulatory DNA elements upstream of genes is the fundamental step in controlling gene expression. How does the necessity to provide stability with respect to mutation constrain the organization of transcription control networks? We examine the mutation load of a transcription factor interacting with a set of n regulatory response elements as a function of the factor/DNA binding specificity and conclude on theoretical grounds that the optimal… CONTINUE READING
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