Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.

  title={Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.},
  author={Elisa A. Waxman and Benoit I Giasson},
  journal={Journal of neuropathology and experimental neurology},
  volume={67 5},
alpha-Synuclein (alpha-syn) is the major component of pathologic inclusions that characterize neurodegenerative disorders such as Parkinson disease, dementia with Lewy body disease, and multiple system atrophy. The present study uses novel phospho-specific antibodies to assess the presence and regulation of phosphorylated Ser87 and Ser129 in alpha-syn in human brain samples and in a transgenic mouse model of alpha-synucleinopathies. By immunohistochemistry, alpha-syn phosphorylated at Ser129… CONTINUE READING
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