Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1).

  title={Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1).},
  author={St{\'e}phane Hausmann and Stewart Shuman},
  journal={The Journal of biological chemistry},
  volume={280 6},
The 2,2,7-trimethylguanosine (TMG) cap structure is characteristic of certain eukaryotic small nuclear and small nucleolar RNAs. Prior studies have suggested that cap trimethylation might be contingent on cis-acting elements in the RNA substrate, protein components of a ribonucleoprotein complex, or intracellular localization of the RNA substrate. However, the enzymatic requirements for TMG cap formation remain obscure because TMG synthesis has not been reconstituted in vitro from defined… CONTINUE READING
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