Specificity and functionality of microRNA inhibitors

@inproceedings{Robertson2010SpecificityAF,
  title={Specificity and functionality of microRNA inhibitors},
  author={Barbara Robertson and Andrew B. Dalby and Jon M Karpilow and Anastasia Khvorova and Devin Leake and Annaleen Vermeulen},
  booktitle={Silence},
  year={2010}
}
BACKGROUND Micro(mi)RNAs regulate gene expression through translational attenuation and messenger (m)RNA degradation, and are associated with differentiation, homeostasis and disease. Natural miRNA target recognition is determined primarily by perfect complementarity in a seed region (nucleotide positions 2 to 7) with additional interactions contributing in a sequence- and target-specific manner. Synthetic miRNA target analogs, which are fully complementary, chemically modified oligonucleotides… CONTINUE READING

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