Specificity and functionality of microRNA inhibitors

  title={Specificity and functionality of microRNA inhibitors},
  author={Barbara A. Robertson and Andrew B. Dalby and J. Karpilow and A. Khvorova and D. Leake and Annaleen Vermeulen},
  pages={10 - 10}
  • Barbara A. Robertson, Andrew B. Dalby, +3 authors Annaleen Vermeulen
  • Published 2010
  • Medicine, Biology
  • Silence
  • BackgroundMicro(mi)RNAs regulate gene expression through translational attenuation and messenger (m)RNA degradation, and are associated with differentiation, homeostasis and disease. Natural miRNA target recognition is determined primarily by perfect complementarity in a seed region (nucleotide positions 2 to 7) with additional interactions contributing in a sequence- and target-specific manner. Synthetic miRNA target analogs, which are fully complementary, chemically modified oligonucleotides… CONTINUE READING

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