Specificity and functionality of microRNA inhibitors

  title={Specificity and functionality of microRNA inhibitors},
  author={Barbara Robertson and Andrew B. Dalby and Jon M Karpilow and Anastasia Khvorova and Devin Leake and Annaleen Vermeulen},
BACKGROUND Micro(mi)RNAs regulate gene expression through translational attenuation and messenger (m)RNA degradation, and are associated with differentiation, homeostasis and disease. Natural miRNA target recognition is determined primarily by perfect complementarity in a seed region (nucleotide positions 2 to 7) with additional interactions contributing in a sequence- and target-specific manner. Synthetic miRNA target analogs, which are fully complementary, chemically modified oligonucleotides… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 43 references

Potent inhibition of microRNA in vivo without degradation

Nucleic acids research • 2009
View 9 Excerpts
Highly Influenced

Gait MJ: miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNApeptide conjugates

MM Fabani
RNA • 2008
View 10 Excerpts
Highly Influenced

Specificity, duplex degradation and subcellular localization of antagomirs

Nucleic acids research • 2007
View 10 Excerpts
Highly Influenced

ATP-dependent human RISC assembly pathways

Nature Structural &Molecular Biology • 2010
View 1 Excerpt

Biogenesis of small RNAs in animals

Nature Reviews Molecular Cell Biology • 2009
View 1 Excerpt

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