Specificity and function of immunoglobulin superfamily NK cell inhibitory and stimulatory receptors.

@article{Colonna1997SpecificityAF,
  title={Specificity and function of immunoglobulin superfamily NK cell inhibitory and stimulatory receptors.},
  author={Marco Colonna},
  journal={Immunological reviews},
  year={1997},
  volume={155},
  pages={127-33}
}
Human NK cells express clonally distributed receptors specific for HLA-A, -B and -C molecules. These receptors belong to the immunoglobulin superfamily and can be functionally distinguished as inhibitory or stimulatory. Inhibitory receptors block NK-cell-mediated cytotoxicity upon binding to HLA class I ligands. This function is mediated by phosphorylation of cytoplasmic tyrosines, which recruit the protein tyrosine phosphatase SHP-1. Stimulatory receptors also bind HLA class I, lack… CONTINUE READING