Specificity and completion time distributions of biochemical processes.

@article{Munsky2009SpecificityAC,
  title={Specificity and completion time distributions of biochemical processes.},
  author={Brian Munsky and Ilya Nemenman and Golan Bel},
  journal={The Journal of chemical physics},
  year={2009},
  volume={131 23},
  pages={235103}
}
In order to produce specific complex structures from a large set of similar biochemical building blocks, many biochemical systems require high sensitivity to small molecular differences. The first and most common model used to explain this high specificity is kinetic proofreading, which has been extended to a variety of systems from detection of DNA mismatch to cell signaling processes. While the specification properties of kinetic proofreading models are well known and were studied in various… CONTINUE READING