Specificity and cellular distribution of human polymorphonuclear leucocyte receptors for leukotriene C4.


Human polymorphonuclear (PMN) leucocytes bind synthetic [3H]-labelled leukotriene C4 ([3H]LTC4) with rapid saturation and reversibility of approximately 90%, by a 700-fold higher concentration of non-radioactive LTC4. [3H]LTC4 is recognized specifically by 10,778 +/- 6260 (mean +/- SD) sites per PMN leucocyte that exhibit a KD of 34.3 +/- 1.7 nM. The… (More)


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