Specificity, tolerance and developmental regulation of natural killer cells defined by expression of class I-specific Ly49 receptors.

@article{Raulet1997SpecificityTA,
  title={Specificity, tolerance and developmental regulation of natural killer cells defined by expression of class I-specific Ly49 receptors.},
  author={David H Raulet and Werner Held and Isabel Leal Azevedo Corr{\^e}a and Jeffrey R. Dorfman and Mengfeng F Wu and Laura Corral},
  journal={Immunological reviews},
  year={1997},
  volume={155},
  pages={41-52}
}
Natural killer cells in the mouse express class I MHC-specific inhibitory receptors of the Ly49 protein family. The receptors mediate inhibition of the lysis of tumor cells and normal cells, and mediate the specificity of bone-marrow graft rejection by NK cells in vivo. The function of these receptors may be to confer upon NK cells the capacity to distinguish normal self cells from cells that have down-regulated expression of some or all self-class I molecules. Ly49 receptors discriminate… CONTINUE READING

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