Specificities of multiple sclerosis cerebrospinal fluid and serum antibodies against mimotopes

@article{JolivetReynaud1998SpecificitiesOM,
  title={Specificities of multiple sclerosis cerebrospinal fluid and serum antibodies against mimotopes},
  author={Colette Jolivet-Reynaud and Herv{\'e} Perron and L. Generenez and Pascal Dalbon and B. Montrant},
  journal={Journal of Neuroimmunology},
  year={1998},
  volume={90}
}
In order to characterize antigenic epitopes specifically targeted by the immune response of patients with multiple sclerosis (MS), the antibody specificities of cerebrospinal fluids (CSF) and sera from the same MS patients have been analyzed using a random pentadecapeptide library displayed on phage. The 3 peptides (mimotopes) selected with MS sera were not disease-specific. In contrast, the combination of 4 MS CSF selected mimotopes, allowed the detection of specific antibodies in 21 of 60 MS… CONTINUE READING

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