Specification of tissue-resident macrophages during organogenesis

@article{Mass2016SpecificationOT,
  title={Specification of tissue-resident macrophages during organogenesis},
  author={E Mass and Iv{\'a}n Ballesteros and Matthias Farlik and Florian Halbritter and Patrick G{\"u}nther and Lucile Crozet and Christian E Jacome-Galarza and Kristian H{\"a}ndler and Johanna Klughammer and Yasuhiro Kobayashi and Elisa Gomez-Perdiguero and Joachim L. Schultze and Marc Beyer and Christoph Bock and Fr{\'e}d{\'e}ric Geissmann},
  journal={Science},
  year={2016},
  volume={353}
}
Tissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors in mice generate premacrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day 9.5 in a chemokine-receptor–dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in… CONTINUE READING
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