Specification of the phenotype required for men with monoamine oxidase type A deficiency

@article{Hebebrand1995SpecificationOT,
  title={Specification of the phenotype required for men with monoamine oxidase type A deficiency},
  author={Johannes Hebebrand and Birgit Klug},
  journal={Human Genetics},
  year={1995},
  volume={96},
  pages={372-376}
}
Brunner et al. (1993 a, b) reported on a Dutch family, in which complete monoamine oxidase type A (MAO-A) deficiency due to a point mutation in the respective gene is associated with a "recognizable behavioral phenotype" (all quotations refer to Brunner et al. 1993 a, b) that includes distrubed regulation of impulsive aggression. Understandably, these findings received considerable coverage in both the scientific (Morell 1993) and lay press, because for the first time aggressive behavior had… 

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Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.

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Normal platelet MAOB activity suggests that the unusual behavior pattern in this family may be caused by isolated MAOA deficiency, which is compatible with a primary defect in the structural gene for MAOA and/or monoamine oxidase type B (MAOB).

Evidence found for a possible 'aggression gene'.

Evidence is reported suggesting that a mutation in the gene for monoamine oxidase A (MAOA) may underlie the aggressive and sometimes violent behavior displayed by certain males in this family.

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a) all of the individuals that we consider unaffected, had at least completed normal primary education. In contrast, only one out of eight affected males has completed normal primary education

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1993 a, b). In their reply Brunner and Ropers now point out that all predigree members whose DNA

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