Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube

@article{Muroyama2005SpecificationOA,
  title={Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube},
  author={Yuko Muroyama and Yuko Fujiwara and Stuart H. Orkin and David H. Rowitch},
  journal={Nature},
  year={2005},
  volume={438},
  pages={360-363}
}
Astrocytes are the most abundant and functionally diverse glial population in the vertebrate central nervous system (CNS). However, the mechanisms underlying astrocyte specification are poorly understood. It is well established that cellular diversification of neurons in the embryo is generated by position-dependent extrinsic signals and combinatorial interactions of transcription factors that direct specific cell fates by suppressing alternative fates. It is unknown whether a comparable… 
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