Specification of Jaw Subdivisions by Dlx Genes

@article{Depew2002SpecificationOJ,
  title={Specification of Jaw Subdivisions by Dlx Genes},
  author={Michael J. Depew and Thomas Lufkin and John L. R. Rubenstein},
  journal={Science},
  year={2002},
  volume={298},
  pages={381 - 385}
}
The success of vertebrates was due in part to the acquisition and modification of jaws. Jaws are principally derived from the branchial arches, embryonic structures that exhibit proximodistal polarity. To investigate the mechanisms that specify the identity of skeletal elements within the arches, we examined mice lacking expression ofDlx5 and Dlx6, linked homeobox genes expressed distally but not proximally within the arches.Dlx5/6–/– mutants exhibit a homeotic transformation of lower jaws to… 
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