Specific unresponsiveness to a retrovirally-transferred class I antigen is controlled through the helper pathway.

@article{Fraser1995SpecificUT,
  title={Specific unresponsiveness to a retrovirally-transferred class I antigen is controlled through the helper pathway.},
  author={Christopher C. Fraser and Megan Sykes and Richard Y. Lee and David H Sachs and Christian Leguern},
  journal={Journal of immunology},
  year={1995},
  volume={154 4},
  pages={1587-95}
}
To investigate the potential role for gene therapy in induction of tolerance to solid organ grafts, we used a murine model based on the introduction of an allogeneic MHC class I gene (H-2Kb) into hematopoietic cells of congenic animals differing only at the class I locus. The H-2Kb gene was placed into a retroviral vector under the control of regulatory sequences of the myeloproliferative sarcoma virus long terminal repeat. Transplantation of H-2Kb retrovirus-transduced autologous bone marrow… CONTINUE READING
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