Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.

@article{Oser2010SpecificTP,
  title={Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.},
  author={Matthew Oser and C. C. Mader and Hava Gil-Henn and Marco A. de Magalh{\~a}es and Jose Javier Bravo-Cordero and Anthony J Koleske and John S Condeelis},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 21},
  pages={3662-73}
}
Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells enriched in proteins that regulate actin polymerization. The on-off regulatory switch that initiates actin polymerization in invadopodia requires phosphorylation of tyrosine residues 421, 466, and 482 on cortactin. However, it is unknown which of these cortactin tyrosine phosphorylation sites control actin polymerization. We investigated the contribution of individual tyrosine phosphorylation sites (421, 466, and… CONTINUE READING