Specific transcriptional enhancement of inducible nitric oxide synthase by targeted promoter demethylation.

Abstract

The ability to specifically reactivate epigenetically silenced genes would have great utility in experimental studies and potential therapeutic value. Here, we describe the specific targeting of thymidine DNA glycosylase (TDG), an enzyme involved in the mechanism of methylcytosine demethylation, to the promoter of Nos2, a gene silenced by methylation in… (More)
DOI: 10.4161/epi.26267

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