Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times.

@article{Blume1993SpecificTW,
  title={Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times.},
  author={Gabriele Blume and Gregor Cevc and M D Crommelin and Irma A. J. M. Bakker-Woudenberg and Cornelis Kluft and Gert Storm},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1149 1},
  pages={180-4}
}
One possibility for bringing drugs to their specific targets is to use the drug-laden liposomes that have been made target-specific by the attachment of appropriate proteins. Such 'directed' proteoliposomes and most other particles are rapidly removed from the bloodstream, however, by the mononuclear phagocytes in the liver and spleen. This causes… CONTINUE READING