Specific targeting of human peripheral blood T cells by heteroaggregates containing anti-T3 crosslinked to anti-target cell antibodies

@article{Prez1986SpecificTO,
  title={Specific targeting of human peripheral blood T cells by heteroaggregates containing anti-T3 crosslinked to anti-target cell antibodies},
  author={Paloma P{\'e}rez and Robert W. Hoffman and Julie A. Titus and David M. Segal},
  journal={The Journal of Experimental Medicine},
  year={1986},
  volume={163},
  pages={166 - 178}
}
Antibody heteroaggregates have been used to render human peripheral blood T cells lytic for specified targets. The heteroaggregates contain anti-T3 covalently linked to antibodies against nominal target cell antigens. Such heteroaggregates bind target cells directly to T3 molecules on effector cells and trigger target cell lysis. Freshly prepared human PBL, when coated with anti-T3-containing heteroaggregates, are lytic without further stimulation, although brief exposure to crude lymphokine… CONTINUE READING