Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody

@article{Prez1985SpecificTO,
  title={Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody},
  author={Pilar P{\'e}rez and Robert W. Hoffman and Stephen Shaw and Jeffrey A Bluestone and David M. Segal},
  journal={Nature},
  year={1985},
  volume={316},
  pages={354-356}
}
The specificity of cytotoxic T lymphocytes (Tc) cells is conferred by an antigen-specific receptor, Ti, which in humans is physically associated with an invariant cell-surface glycoprotein, T3 (refs. 1–3). Monoclonal antibodies specific for either T3 and Ti are able to elicit a variety of T-cell responses such as lymphokine production, mitogenesis and cytotoxicity1–11. For example, human Tc cells lyse anti-T3-expressing hybridoma cells, but not cells of other specificity, presumably because… CONTINUE READING