Specific suppression of allograft rejection by trinitrophenyl (TNP)- induced suppressor cells in recipients treated with TNP-haptenated donor alloantigens

@article{Hutchinson1985SpecificSO,
  title={Specific suppression of allograft rejection by trinitrophenyl (TNP)- induced suppressor cells in recipients treated with TNP-haptenated donor alloantigens},
  author={Ian V. Hutchinson and William Howard Barber and Peter J. Morris},
  journal={The Journal of Experimental Medicine},
  year={1985},
  volume={162},
  pages={1409 - 1420}
}
Suppressor T cells, activated by injection of trinitrobenzene sulphonic acid in DA rats, prevented rejection of LEW kidney allografts in a donor-specific manner when adoptively transferred into syngeneic recipients along with trinitrophenyl (TNP)-haptenated LEW alloantigen. TNP-haptenated third-party alloantigen was ineffective in this system. The donor-specific suppression was dependent, too, on the haptenic portion of the chemically modified alloantigen. Hence, fluorescein isothiocyanate… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Mechanisms of kidney allograft maintenance in rats treated with cyclosporine. Transplant

  • W. H. Barber, I. V. Hutchinson, P. J. Morris
  • 1985
Highly Influential
5 Excerpts