Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates.

@article{Park2005SpecificSI,
  title={Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates.},
  author={Steven Y Park and Rosemarie Kelly and Jennifer Nielsen Kahn and Jorge Mu{\~n}oz Robles and M-J Hsu and Elizabeth A. Register and Wen-Jun Li and Vishal Vyas and Huiying Fan and George K. Abruzzo and Amy M Flattery and Charles J. Gill and Gary L Chrebet and Stephen A. Parent and Myra Kurtz and Hedy Teppler and Cameron M Douglas and David Scott Perlin},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 8},
  pages={3264-73}
}
An association between reduced susceptibility to echinocandins and changes in the 1,3-beta-d-glucan synthase (GS) subunit Fks1p was investigated. Specific mutations in fks1 genes from Saccharomyces cerevisiae and Candida albicans mutants are described that are necessary and sufficient for reduced susceptibility to the echinocandin drug caspofungin. One group of amino acid changes in ScFks1p, ScFks2p, and CaFks1p defines a conserved region (Phe 641 to Asp 648 of CaFks1p) in the Fks1 family of… CONTINUE READING
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