Specific site methylation in the 5'-flanking region of CYP1A2 interindividual differences in human livers.

@article{Hammons2001SpecificSM,
  title={Specific site methylation in the 5'-flanking region of CYP1A2 interindividual differences in human livers.},
  author={George Hammons and Yan Yan-Sanders and Bao-feng Jin and Ernice Blann and Fred F. Kadlubar and Beverly D. Lyn-Cook},
  journal={Life sciences},
  year={2001},
  volume={69 7},
  pages={839-45}
}
Human cytochrome P4501A2 (CYP1A2) is involved in the metabolism of a large number of common drugs and is responsible for the metabolic activation of numerous promutagens and procarcinogens. Large interindividual differences exist in the expression of this enzyme. This variability has important implications for drug efficacy and cancer susceptibility. In this sudy, the methylation status of the CCGG site (bp -2759) located adjacent to an AP-1 site in the 5'-flanking region of the CYP1A2 gene was… CONTINUE READING

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