Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-beta1.

@article{Haydont2008SpecificSI,
  title={Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-beta1.},
  author={Val{\'e}rie Haydont and Bruce L. Riser and Jocelyne Aigueperse and Marie-Catherine Vozenin-Brotons},
  journal={American journal of physiology. Cell physiology},
  year={2008},
  volume={294 6},
  pages={C1332-41}
}
The fibrogenic differentiation of resident mesenchymal cells is a key parameter in the pathogenesis of radiation fibrosis and is triggered by the profibrotic growth factors transforming growth factor (TGF)-beta1 and CCN2. TGF-beta1 is considered the primary inducer of fibrogenic differentiation and is thought to control its long-term maintenance, whereas CCN2 is considered secondary effector of TGF-beta1. Yet, in long-term established fibrosis like that associated with delayed radiation… CONTINUE READING