Specific serotonin reuptake inhibitor-induced decreases in lymphocyte activity require endogenous serotonin release.

@article{Pellegrino2000SpecificSR,
  title={Specific serotonin reuptake inhibitor-induced decreases in lymphocyte activity require endogenous serotonin release.},
  author={Trisha C. Pellegrino and Barbara M. Bayer},
  journal={Neuroimmunomodulation},
  year={2000},
  volume={8 4},
  pages={179-87}
}
OBJECTIVES We have previously reported that acute administration of the specific serotonin reuptake inhibitor (SSRI), fluoxetine, resulted in a decrease in mitogen-induced blood lymphocyte proliferation. The present studies further examine the specificity of this response to serotonin reuptake systems and the potential role of endogenous serotonin in mediating these effects. METHODS Male Sprague-Dawley rats were treated intraperitoneally with the SSRIs, fluoxetine (6-10 mg/kg) or sertraline… CONTINUE READING