Specific serotonergic reuptake inhibition impairs vigilance performance acutely and after subchronic treatment

  title={Specific serotonergic reuptake inhibition impairs vigilance performance acutely and after subchronic treatment},
  author={Wim J. Riedel and Karin J L Eikmans and Annet Heldens and Jeroen A. J. Schmitt},
  journal={Journal of Psychopharmacology},
  pages={12 - 20}
Subchronic treatment with the selective serotonergic reuptake inhibitors (SSRIs) fluoxetine, venlafaxine and paroxetine, but not sertraline, were previously shown to specifically impair vigilance performance. The current study was designed to compare the vigilance effects of subchronic treatment with the SSRIs sertraline and citalopram in healthy volunteers, according to a placebo-controlled, double-blind, three-way cross-over design. Twenty-four healthy subjects, aged 30-50 years, of whom 21… 

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