Specific sequence of a Beta turn in human la protein may contribute to species specificity of hepatitis C virus.

@article{Kumar2014SpecificSO,
  title={Specific sequence of a Beta turn in human la protein may contribute to species specificity of hepatitis C virus.},
  author={Anuj Kumar and Asit Kumar Manna and Upasana Ray and Ranajoy Mullick and Gautam Basu and Saumitra Das and Siddhartha Roy},
  journal={Journal of virology},
  year={2014},
  volume={88 8},
  pages={4319-27}
}
UNLABELLED Human La protein is known to be an essential host factor for translation and replication of hepatitis C virus (HCV) RNA. Previously, we have demonstrated that residues responsible for interaction of human La protein with the HCV internal ribosomal entry site (IRES) around the initiator AUG within stem-loop IV form a β-turn in the RNA recognition motif (RRM) structure. In this study, sequence alignment and mutagenesis suggest that the HCV RNA-interacting β-turn is conserved only in… CONTINUE READING

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