Specific routing of retinal ganglion cell axons at the mammalian optic chiasm during embryonic development.

@article{Sretavan1990SpecificRO,
  title={Specific routing of retinal ganglion cell axons at the mammalian optic chiasm during embryonic development.},
  author={David W. Sretavan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1990},
  volume={10 6},
  pages={1995-2007}
}
During development of the mammalian CNS, axons encounter multiple pathway choices on their way to central target structures. A major pathway branch point in the visual system occurs at the optic chiasm, where retinal ganglion cell axons may either enter the ipsilateral or the contralateral optic tract. To investigate whether embryonic mouse retinal ganglion cell axons, upon reaching the optic chiasm, selectively grow into the correct pathway, developing retinal ganglion cells were retrogradely… CONTINUE READING
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