Specific role for the extracellular signal-regulated kinase pathway in angiotensin II- but not phenylephrine-induced cardiac hypertrophy in vitro

@article{Ruf2001SpecificRF,
  title={Specific role for the extracellular signal-regulated kinase pathway in angiotensin II- but not phenylephrine-induced cardiac hypertrophy in vitro},
  author={Stefan Ruf and Hans Michael Piper and K. -D. Schl{\"u}ter},
  journal={Pfl{\"u}gers Archiv},
  year={2001},
  volume={443},
  pages={483-490}
}
The study addressed the question of why in adult ventricular rat cardiomyocytes ERK activation is required for the hypertrophic stimulation caused by angiotensin II but not in the case of α-adrenoceptor stimulation. We therefore compared in the same culture system the intracellular signaling steps that are involved in inducing the hypertrophic growth evoked by stimulating either of these two receptors. α-Adrenoceptor stimulation strongly increased protein synthesis ([14C]phenylalanine… CONTINUE READING

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