Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides

@article{Wilton1999SpecificRO,
  title={Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides},
  author={S. Wilton and F. Lloyd and K. Carville and S. Fletcher and R. Kole},
  journal={Neuromuscular Disorders},
  year={1999},
  volume={9},
  pages={330-338}
}
  • S. Wilton, F. Lloyd, +2 authors R. Kole
  • Published 1999
  • Medicine, Biology
  • Neuromuscular Disorders
  • The mdx mouse, which carries a nonsense mutation in exon 23 of the dystrophin gene, has been used as an animal model of Duchenne muscular dystrophy to evaluate cell or gene replacement therapies. Despite the mdx mutation, which should preclude the synthesis of a functional dystrophin protein, rare, naturally occurring dystrophin-positive fibres have been observed in mdx muscle tissue. These dystrophin-positive fibres are thought to have arisen from an exon-skipping mechanism, either somatic… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 150 CITATIONS, ESTIMATED 44% COVERAGE

    Antisense-induced multiexon skipping for Duchenne muscular dystrophy makes more sense.

    VIEW 3 EXCERPTS
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    1999
    2020

    CITATION STATISTICS

    • 3 Highly Influenced Citations