Specific regulatory motifs predict glucocorticoid responsiveness of hippocampal gene expression.

@article{Datson2011SpecificRM,
  title={Specific regulatory motifs predict glucocorticoid responsiveness of hippocampal gene expression.},
  author={Nicole A Datson and J Annelies E Polman and Robert T de Jonge and P T M van Boheemen and Eline M T van Maanen and Joke Welten and Bruce S. McEwen and Hugo C Meiland and Onno C. Meijer},
  journal={Endocrinology},
  year={2011},
  volume={152 10},
  pages={3749-57}
}
The glucocorticoid receptor (GR) is an ubiquitously expressed ligand-activated transcription factor that mediates effects of cortisol in relation to adaptation to stress. In the brain, GR affects the hippocampus to modulate memory processes through direct binding to glucocorticoid response elements (GREs) in the DNA. However, its effects are to a high degree cell specific, and its target genes in different cell types as well as the mechanisms conferring this specificity are largely unknown. To… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…