Specific regulation of E2F family members by cyclin-dependent kinases.

  title={Specific regulation of E2F family members by cyclin-dependent kinases.},
  author={Brian D. Dynlacht and Kirk D. Moberg and Jacqueline A Lees and E E Harlow and Liang Zhu},
  journal={Molecular and cellular biology},
  volume={17 7},
The transcription factor E2F-1 interacts stably with cyclin A via a small domain near its amino terminus and is negatively regulated by the cyclin A-dependent kinases. Thus, the activities of E2F, a family of transcription factors involved in cell proliferation, are regulated by at least two types of cell growth regulators: the retinoblastoma protein family and the cyclin-dependent kinase family. To investigate further the regulation of E2F by cyclin-dependent kinases, we have extended our… CONTINUE READING
37 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…