Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Abstract

Regulatory T (Treg) cells mediate homeostatic peripheral tolerance by suppressing autoreactive T cells. Failure of host antitumor immunity may be caused by exaggerated suppression of tumor-associated antigen–reactive lymphocytes mediated by Treg cells; however, definitive evidence that Treg cells have an immunopathological role in human cancer is lacking… (More)
DOI: 10.1038/nm1093

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Cite this paper

@article{Curiel2004SpecificRO, title={Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival}, author={Tyler Jay Curiel and George Coukos and Linhua Zou and Xavier Alvarez and Pui Joan Cheng and Peter J Mottram and Melina Evdemon-Hogan and Jos{\'e} Ram{\'o}n Conejo-Garcia and Lin Zhang and Matthew E. Burow and Yun Zhu and Shuang Wei and Ilona Kryczek and Ben Daniel and A. Wilson Gordon and Leann Myers and Andrew A Lackner and Mary Lenora Disis and Keith L. Knutson and Lieping Chen and Weiping Zou}, journal={Nature Medicine}, year={2004}, volume={10}, pages={942-949} }