Specific recognition of apoptotic cells reveals a ubiquitous and unconventional innate immunity.

@article{Cvetanovic2006SpecificRO,
  title={Specific recognition of apoptotic cells reveals a ubiquitous and unconventional innate immunity.},
  author={Marija Cvetanovic and Justin E. Mitchell and Vimal Patel and Benjamin S. Avner and Yan Su and Paul T van der Saag and Pamela L. Witte and Stefano Fiore and Jerrold S. Levine and David S. Ucker},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 29},
  pages={
          20055-67
        }
}
The purpose of physiological cell death is the noninflammatory clearance of cells that have become inappropriate or nonfunctional. Consistent with this function, the recognition of apoptotic cells by professional phagocytes, including macrophages and dendritic cells, triggers a set of potent anti-inflammatory responses manifest on multiple levels. The immediate-early inhibition of proinflammatory cytokine gene transcription in the phagocyte is a proximate consequence of recognition of the… CONTINUE READING

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