Specific recognition mechanism between RNA and the KH3 domain of Nova-2 protein.


The KH3 domain of Nova-2 protein can precisely recognize the sequence-specific target RNA of human glycine receptor α2. However, the recognition mechanism between the protein and its target RNA is still hotly debated. In this study, molecular dynamic simulations in explicit solvent were utilized to understand the recognition mechanism. The structural… (More)
DOI: 10.1021/jp5079289